抄録
The subventricular zone (SVZ) is the largest neurogenic region in the adult rodent brain. In this region, new neurons that originate from neural stem cells (NSCs) migrate to the olfactory bulb, where they mature into interneurons. During neurogenesis, the proliferation of NSCs and neuronal progenitor cells are precisely regulated by multiple signaling pathways to maintain homeostasis. Wnt signaling is one mechanism that controls the proliferation of SVZ cells. In addition to NSCs and progenitor cells, the migration of new neurons (neuroblasts) also maintains the proliferative capacity. Recently, Diversin, which is a component of the Wnt signaling pathway, has been shown to promote the proliferation of neuroblasts in the SVZ. Neuroblast proliferation may be an important step in regenerative responses to brain injury and in normal physio–logical neurogenesis.
| 本文言語 | English |
|---|---|
| ホスト出版物のタイトル | Tumors of the Central Nervous System, Volume 9 |
| ホスト出版物のサブタイトル | Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas |
| 出版社 | Springer Netherlands |
| ページ | 177-183 |
| ページ数 | 7 |
| ISBN（電子版） | 9789400754881 |
| ISBN（印刷版） | 9789400754874 |
| DOI | |
| 出版ステータス | Published - 2012 1月 1 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 医学（全般）