Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity

Gulzar Hussain Shah; Kazuhiro Kataoka; Akiko Ueno; Yoshihisa Ohtsuka; Tohru Mizushima; Kazuhisa Sekimizu

doi:10.1248/bpb.20.1233

Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity

Gulzar Hussain Shah, Kazuhiro Kataoka, Akiko Ueno, Yoshihisa Ohtsuka, Tohru Mizushima, Kazuhisa Sekimizu

薬学科

研究成果: Article › 査読

抄録

The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, suppressed the inhibitory effect of cardiolipin. The present results suggest that relaxation of DNA supercoiling is involved in the cytotoxic action of these drugs.

本文言語	English
ページ（範囲）	1233-1234
ページ数	2
ジャーナル	Biological and Pharmaceutical Bulletin
巻	20
号	12
DOI	https://doi.org/10.1248/bpb.20.1233
出版ステータス	Published - 1997 1月 1

ASJC Scopus subject areas

薬理学
薬科学

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10.1248/bpb.20.1233

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abstract = "The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, suppressed the inhibitory effect of cardiolipin. The present results suggest that relaxation of DNA supercoiling is involved in the cytotoxic action of these drugs.",

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AU - Ohtsuka, Yoshihisa

AU - Mizushima, Tohru

AU - Sekimizu, Kazuhisa

PY - 1997/1/1

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N2 - The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, suppressed the inhibitory effect of cardiolipin. The present results suggest that relaxation of DNA supercoiling is involved in the cytotoxic action of these drugs.

AB - The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, suppressed the inhibitory effect of cardiolipin. The present results suggest that relaxation of DNA supercoiling is involved in the cytotoxic action of these drugs.

KW - Acidic phospholipid

KW - Cardiolipin

KW - Chlorpromazine

KW - Cytotoxicity

KW - DNA topoisomerase 1

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Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity

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