Pulmonary toxicity of indium tin oxide and copper indium gallium diselenide

Akiyo Tanaka, Miyuki Hirata, Kazunori Koga, Makiko Nakano, Kazuyuki Omae, Yutaka Kiyohara

研究成果: Conference contribution

4 被引用数 (Scopus)


The aim of this review is to introduce the adverse health effects of indium compounds. This review consists of 2 parts: (1) a study of the toxic effects of indium compounds in humans, and (2) a study of the toxic effects of indium tin oxide (ITO) and copper indium gallium diselenide (CIGS) in animals. To date, 4 epidemiological surveys have been conducted of indium-handling workers in Japan, and all who were studied showed that exposure to indium compounds caused pulmonary interstitial and emphysematous changes. There were clear dose-response and dose-effect relationships between the serum indium levels and the levels of Krebs von den Lungen-6 (KL-6), which is a serological indicator of interstitial pneumonia. Up until 2011, 8 cases of interstitial pneumonia in Japanese indium-exposed workers, 2 cases of pulmonary alveolar proteinosis (PAP) in US indium-exposed workers, and 1 case of PAP in a Chinese indium-exposed worker have been reported. In animal studies, it has been clearly demonstrated that ITO and CIGS particles cause pulmonary toxicity and that the dissolution of ITO and CIGS particles in the lungs is considerably slow when repeated intratracheal instillations were given to experimental animals. Thus, more studies are needed on the effects of human exposure to indium compounds.

ホスト出版物のタイトルPlasma Processing and Diagnostics for Life Sciences
出版ステータスPublished - 2012
イベント2012 MRS Spring Meeting - San Francisco, CA, United States
継続期間: 2012 4月 92012 4月 13


名前Materials Research Society Symposium Proceedings


Other2012 MRS Spring Meeting
国/地域United States
CitySan Francisco, CA

ASJC Scopus subject areas

  • 材料科学一般
  • 凝縮系物理学
  • 材料力学
  • 機械工学


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