Questionnaire survey of acute and delayed adverse reactions to ferumoxides

Tadayoshi Kurata, Akihiro Tanimoto, Hiroshi Shinmoto, Yuji Yuasa, Sachio Kuribayashi

研究成果: Article査読

3 被引用数 (Scopus)


Purpose: The purpose of this study was to assess acute and delayed adverse reactions to ferumoxides. Materials and Methods: 473 consecutive patients who underwent ferumoxides-enhanced MRI were enrolled in this study. Following non-contrast-enhanced MRI, patients were interviewed about their allergic history, and after ferumoxides-enhanced MRI, they were asked to fill out a questionnaire sheet to record any symptoms within one week. Results: 345 of 473 questionnaires (72.9%) were returned. Fifty-eight of 345 patients (16.8%) showed some adverse reactions considered to be related to ferumoxides: 25 (7.2%) during administration, 25 (7.2%) later on the day of ferumoxides administration, and 17 (4.9%) within one week. Thirty-three patients (9.6%) showed only delayed adverse reactions. Delayed adverse reactions were more frequent in women than in men (p<0.01), and in patients with any allergic history than in those without such history (p<0.05). Acute adverse reactions tended to be more frequent in patients who had some adverse events to any contrast medium than in those with no such history (p=0.069). Conclusion: By using the questionnaire, the incidence of adverse reactions to ferumoxides (16.8%) was higher than previously reported from Japanese clinical trials.

ジャーナルRadiation Medicine - Medical Imaging and Radiation Oncology
出版ステータスPublished - 2005 11月

ASJC Scopus subject areas

  • 放射線
  • 放射線学、核医学およびイメージング
  • 腫瘍学


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