TY - JOUR
T1 - Rapid increase in plasma nitrite concentration following intravenous administration of nipradilol
AU - Adachi, Takeshi
AU - Hori, Shingo
AU - Miyazaki, Koji
AU - Takahashi, Eiichi
AU - Nakagawa, Masahiro
AU - Udagawa, Akira
AU - Hayashi, Nariyuki
AU - Aikawa, Naoki
AU - Ogawa, Satoshi
PY - 1995/11/14
Y1 - 1995/11/14
N2 - Nipradilol, a β-adrenoceptor antagonist with vasodilator activity, has a structure which contains a NO2 group. In anesthetized dogs, the time course of the systemic vasodilatation and plasma nitrite (NO-2) concentration was studied following intravenous administration of nipradilol (1 mg/kg). A fall in systemic vascular resistance was observed at 1 min, which was rapidly followed by a significant increase in the plasma NO-2 concentration. It is indicated that nipradilol exerts systemic vasodilatation via nitric oxide (NO) release in vivo.
AB - Nipradilol, a β-adrenoceptor antagonist with vasodilator activity, has a structure which contains a NO2 group. In anesthetized dogs, the time course of the systemic vasodilatation and plasma nitrite (NO-2) concentration was studied following intravenous administration of nipradilol (1 mg/kg). A fall in systemic vascular resistance was observed at 1 min, which was rapidly followed by a significant increase in the plasma NO-2 concentration. It is indicated that nipradilol exerts systemic vasodilatation via nitric oxide (NO) release in vivo.
KW - Nipradilol
KW - Nitric oxide (NO)
KW - Nitrite
KW - cGMP
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U2 - 10.1016/0014-2999(95)00559-4
DO - 10.1016/0014-2999(95)00559-4
M3 - Article
C2 - 8605957
AN - SCOPUS:0028846530
SN - 0014-2999
VL - 286
SP - 201
EP - 204
JO - European journal of pharmacology
JF - European journal of pharmacology
IS - 2
ER -