TY - JOUR
T1 - Ratio of Axial Length to Corneal Radius in Japanese Patients and Accuracy of Intraocular Lens Power Calculation Based on Biometric Data
AU - Omoto, Miki Kamikawatoko
AU - Torii, Hidemasa
AU - Hayashi, Ken
AU - Ayaki, Masahiko
AU - Tsubota, Kazuo
AU - Negishi, Kazuno
N1 - Funding Information:
All authors have completed and submitted the ICMJE form for Disclosure of Potential Conflicts of Interest and none were reported. Funding/Support: No outside funding was received for this study. Financial Disclosures: K.N. has received support from Fuji Xerox Co (Tokyo, Japan); and has received personal fees from Alcon Japan (Tokyo, Japan), Santen Pharmaceutical (Osaka, Japan), Hoya (Tokyo, Japan), Abbott Medical Optics (Santa Ana, California), Senju Pharmaceutical (Osaka, Japan), and Kowa (Nagoya, Japan); and has received personal fees from RE Medical Inc. (Osaka, Japan), BLJ (Tokyo, Japan), Wakamoto (Tokyo, Japan), Universal View (Tokyo, Japan), M3 (Tokyo, Japan), Toray Industries (Tokyo, Japan), Chuo Sangio (Hyogo, Japan), Kowa Pharmaceutical (Tokyo, Japan), Otsuka Pharmaceutical (Tokyo, Japan), Qualitas (Tokyo, Japan), NIDEK (Aichi, Japan), and Carl Zeiss Meditec (Jena, Germany); and holds patent rights for potential products for myopia suppression. H.T. has received research support and personal fees from Fuji Xerox (Tokyo, Japan), Otsuka Pharmaceutical (Tokyo, Japan), Santen Pharmaceutical (Osaka, Japan), Hoya (Tokyo, Japan), Alcon Japan (Tokyo, Japan), MediProduce (Tokyo, Japan), Senju Pharmaceutical (Osaka, Japan), Carl Zeiss Meditec (Jena, Germany), Rohto Pharmaceutical (Osaka, Japan), and Tsubota Laboratory, Inc. (Tokyo, Japan). K.T. has received research support and personal fees from Santen Pharmaceutical (Osaka, Japan), Otsuka Pharmaceutical (Tokyo, Japan), Jins (Tokyo, Japan), Wakasa Seikatsu (Kyoto, Japan), Wakamoto Pharmaceutical (Tokyo, Japan), Toshiba Materials (Tokyo, Japan), Asahi Glass (Tokyo, Japan), Toray (Tokyo, Japan), Plus One Marketing (Tokyo, Japan), Laboratoires Thea, AMO Japan K.K. (Tokyo, Japan), Tear Solutions (Tokyo, Japan), Novaliq, Tissue Tech, Kowa (Aichi, Japan), Rohto Pharmaceutical (Osaka, Japan), Pfizer, R-Tech Ueno (Tokyo, Japan), Ophtecs (Hyogo, Japan), Alcon Japan (Tokyo, Japan), NIDEK (Aichi, Japan), Ocular Surface Research & Education Foundation, Tsubota Laboratory (Tokyo, Japan). In addition, patents are pending or granted with Jins (Tokyo, Japan), Asahi Glass (Tokyo, Japan), and Toshiba Materials (Tokyo, Japan). M.O. K.H. and M.A. have reported that they have no relationships relevant to the contents of this paper to disclose. The authors thank Dr. Yasunori Sato (Keio University Hospital Clinical and Translation Research Center) for guidance and support in conducting the statistical analyses. The authors also thank Lynda Charters for English editing.
Publisher Copyright:
© 2020 The Authors
PY - 2020/10
Y1 - 2020/10
N2 - Purpose: To evaluate the features of the axial length-to-corneal radius (AL/CR) ratio in Japanese patients with cataracts and to determine the accuracy of intraocular lens (IOL) power calculation formulas according to the AL/CR features and the axial length (AL). Design: Retrospective observational case series. Methods: Setting was a clinical practice. Patient population was a total of 1,135 eyes (1,135 patients) with cataracts. Observation procedures included measurement of the AL and corenal radius (CR) by optical biometry and evaluation of the refractive outcomes by using the SRK/T, Holladay 1, Hoffer Q, Haigis, and Barrett Universal II formulas. Main outcome measurements were the features of the AL/CR ratio and the accuracy of IOL power calculations based on the AL/CR ratio and the AL. Results: The mean AL/CR ratio was 3.15 ± 0.19. Significant weak negative correlations were observed between the spherical equivalent (SE) and AL (r = −0.7489; P < .001) and between the SE and AL/CR ratio (r = −0.8069; P < .001); no correlation was found between the SE and CR (r = 0.0208, P = .483). For medium ALs and high AL/CR ratios, the SRK/T formula performed less accurately. For long ALs and high AL/CR ratios, the Holladay 1 and Hoffer Q formulas performed less accurately. The Barrett Universal II formula performed well across a range of ALs and AL/CR ratios. Conclusions: The AL/CR ratio explained the total variation in the SE better than the AL alone. Surgeons should pay attention to the selection of IOL power calculation formulas in eyes with high AL/CR ratios.
AB - Purpose: To evaluate the features of the axial length-to-corneal radius (AL/CR) ratio in Japanese patients with cataracts and to determine the accuracy of intraocular lens (IOL) power calculation formulas according to the AL/CR features and the axial length (AL). Design: Retrospective observational case series. Methods: Setting was a clinical practice. Patient population was a total of 1,135 eyes (1,135 patients) with cataracts. Observation procedures included measurement of the AL and corenal radius (CR) by optical biometry and evaluation of the refractive outcomes by using the SRK/T, Holladay 1, Hoffer Q, Haigis, and Barrett Universal II formulas. Main outcome measurements were the features of the AL/CR ratio and the accuracy of IOL power calculations based on the AL/CR ratio and the AL. Results: The mean AL/CR ratio was 3.15 ± 0.19. Significant weak negative correlations were observed between the spherical equivalent (SE) and AL (r = −0.7489; P < .001) and between the SE and AL/CR ratio (r = −0.8069; P < .001); no correlation was found between the SE and CR (r = 0.0208, P = .483). For medium ALs and high AL/CR ratios, the SRK/T formula performed less accurately. For long ALs and high AL/CR ratios, the Holladay 1 and Hoffer Q formulas performed less accurately. The Barrett Universal II formula performed well across a range of ALs and AL/CR ratios. Conclusions: The AL/CR ratio explained the total variation in the SE better than the AL alone. Surgeons should pay attention to the selection of IOL power calculation formulas in eyes with high AL/CR ratios.
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U2 - 10.1016/j.ajo.2020.03.006
DO - 10.1016/j.ajo.2020.03.006
M3 - Article
C2 - 32209342
AN - SCOPUS:85086085431
SN - 0002-9394
VL - 218
SP - 320
EP - 329
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
ER -