TY - JOUR
T1 - Recent advances in the understanding and treatment of pemphigus and pemphigoid [version 1; referees
T2 - 2 approved]
AU - Yamagami, Jun
N1 - Funding Information:
Grant information: Jun Yamagami is supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan and the Keio Gijuku Academic Development Fund.
Publisher Copyright:
© 2018 Yamagami J.
PY - 2018
Y1 - 2018
N2 - Pemphigus and pemphigoid are characterized as autoimmune blistering diseases in which immunoglobulin G autoantibodies cause blisters and erosions of the skin or mucosa or both. Recently, understanding of the pathophysiology of pemphigus and pemphigoid has been furthered by genetic analyses, characterization of autoantibodies and autoreactive B cells, and elucidation of cell–cell adhesion between keratinocytes. For the management of pemphigus and pemphigoid, the administration of systemic corticosteroids still represents the standard treatment strategy; however, evidence of the efficacy of therapies not involving corticosteroids, such as those employing anti-CD20 antibodies, is increasing. The goal should be to develop antigen-specific immune suppression-based treatments.
AB - Pemphigus and pemphigoid are characterized as autoimmune blistering diseases in which immunoglobulin G autoantibodies cause blisters and erosions of the skin or mucosa or both. Recently, understanding of the pathophysiology of pemphigus and pemphigoid has been furthered by genetic analyses, characterization of autoantibodies and autoreactive B cells, and elucidation of cell–cell adhesion between keratinocytes. For the management of pemphigus and pemphigoid, the administration of systemic corticosteroids still represents the standard treatment strategy; however, evidence of the efficacy of therapies not involving corticosteroids, such as those employing anti-CD20 antibodies, is increasing. The goal should be to develop antigen-specific immune suppression-based treatments.
KW - Pemphigoid
KW - Pemphigus
UR - http://www.scopus.com/inward/record.url?scp=85052955262&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052955262&partnerID=8YFLogxK
U2 - 10.12688/f1000research.14474.1
DO - 10.12688/f1000research.14474.1
M3 - Review article
C2 - 30228865
AN - SCOPUS:85052955262
SN - 2046-1402
VL - 7
JO - F1000Research
JF - F1000Research
M1 - 1360
ER -