Recognition of shared melanoma antigens by human tumor-infiltrating lymphocytes

Suzanne L. Topalian, Sophia S. Horn, Yutaka Kawakami, Marie Mancini, Douglas J. Schwartzentruber, Rina Zakut, Steven A. Rosenberg

研究成果: Article査読

18 被引用数 (Scopus)


We have established that melanomas express shared tumor antigens (Ags) that can be recognized by T cells if presented in the context of self-MHC molecules. Tumor-infiltrating lymphocytes (TILs) from six melanoma patients were tested for lysis of large panels of HLA-matched or unmatched targets representing a variety of tissue types. Lysis was specific for allogeneic melanomas sharing at least one HLA-A, -B, or -C Ag with TILs, and demonstrated commonly expressed tumor Ags. Similar findings were obtained when cytokine secretion by TILs was used to indicate specific Ag recognition. Transfection of the HLA-A2.1 gene into HLA-A2- melanoma lines conferred susceptibility to lysis by HLA-A2 restricted melanoma TILs, demonstrating expression of common tumor Ags among patients of diverse HLA types. These findings have important implications for developing broadly applicable cancer immunotherapies such as vaccines.

ジャーナルJournal of Immunotherapy
出版ステータスPublished - 1992 10月

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 薬理学
  • 癌研究


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