Reelin regulates the development and synaptogenesis of the layer- specific entorhino-hippocampal connections

Víctor Borrell, José A. Del Río, Soledad Alcántara, Michèle Derer, Albert Martínez, Gabriella D'Arcangelo, Kazunori Nakajima, Katsuhiko Mikoshiba, Paul Derer, Tom Curran, Eduardo Soriano

研究成果: Article査読

170 被引用数 (Scopus)

抄録

Here we examine the role of Reelin, an extracellular protein involved in neuronal migration, in the formation of hippocampal connections. Both at prenatal and postnatal stages, the general laminar and topographic distribution of entorhinal projections is preserved in the hippocampus of reeler mutant mice, in the absence of Reelin. However, developing and adult entorhinal afferents show severe alterations, including increased numbers of misrouted fibers and the formation of abnormal patches of termination from the medial and lateral entorhinal cortices. At perinatal stages, single entorhinal axons in reeler mice are grouped into thick bundles, and they have decreased axonal branching and decreased extension of axon collaterals. We also show that the number of entorhino-hippocampal synapses is lower in reeler mice than in control animals during development. Studies performed in mixed entorhino-hippocampal cocultures combining slices from reeler and wild- type mice indicate that these abnormalities are caused by the lack of Reelin in the target hippocampus. These findings imply that Reelin fulfills a modulatory role during the formation of layer-specific and topographic connections in the hippocampus. They also suggest that Reelin promotes maturation of single fibers and synaptogenesis by entorhinal afferents.

本文言語English
ページ(範囲)1345-1358
ページ数14
ジャーナルJournal of Neuroscience
19
4
DOI
出版ステータスPublished - 1999 2月 15
外部発表はい

ASJC Scopus subject areas

  • 神経科学一般

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