Regulation of thermoresponsive properties and drug carrier application of nano-micelles via heterogeneous end-functional block copolymer blends

Masamichi Nakayama; Yayoi Kawahara; Hideko Kanazawa; Teruo Okano

Regulation of thermoresponsive properties and drug carrier application of nano-micelles via heterogeneous end-functional block copolymer blends

Masamichi Nakayama, Yayoi Kawahara, Hideko Kanazawa, Teruo Okano

薬科学科

研究成果: Paper › 査読

抄録

We prepared well-defined amphiphilic diblock copolymers comprising thermoresponsive segments and hydrophobic segments by reversible addition-fragmentation chain transfer radical polymerization. Terminal dithiobenzoate groups located at thermoresponsive chains were substituted with hydrophilic maleimede groups. Polymeric micelles were prepared by blend of heterogeneous end-functional diblock copolymers at any ratio in weight, and were characterized regading hydrodynamic diameters and thermoresponsive properties.

本文言語	English
ページ	5455-5456
ページ数	2
出版ステータス	Published - 2006 12月 1
イベント	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan 継続期間: 2006 9月 20 → 2006 9月 22

Other

Other	55th Society of Polymer Science Japan Symposium on Macromolecules
国/地域	Japan
City	Toyama
Period	06/9/20 → 06/9/22

ASJC Scopus subject areas

工学（全般）

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引用スタイル

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T1 - Regulation of thermoresponsive properties and drug carrier application of nano-micelles via heterogeneous end-functional block copolymer blends

AU - Nakayama, Masamichi

AU - Kawahara, Yayoi

AU - Kanazawa, Hideko

AU - Okano, Teruo

PY - 2006/12/1

Y1 - 2006/12/1

N2 - We prepared well-defined amphiphilic diblock copolymers comprising thermoresponsive segments and hydrophobic segments by reversible addition-fragmentation chain transfer radical polymerization. Terminal dithiobenzoate groups located at thermoresponsive chains were substituted with hydrophilic maleimede groups. Polymeric micelles were prepared by blend of heterogeneous end-functional diblock copolymers at any ratio in weight, and were characterized regading hydrodynamic diameters and thermoresponsive properties.

AB - We prepared well-defined amphiphilic diblock copolymers comprising thermoresponsive segments and hydrophobic segments by reversible addition-fragmentation chain transfer radical polymerization. Terminal dithiobenzoate groups located at thermoresponsive chains were substituted with hydrophilic maleimede groups. Polymeric micelles were prepared by blend of heterogeneous end-functional diblock copolymers at any ratio in weight, and were characterized regading hydrodynamic diameters and thermoresponsive properties.

KW - Drug carrier

KW - Poly(N-isopropylacrylamide)

KW - Polymer blend

KW - Polymeric micelle

KW - Reversible addition-fragmentation chain transfer radical polymerization

KW - Thermoresponse

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T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

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