@article{5d728278d00d4546bc9095c7f9d415f4,
title = "Repetitive trigeminal nociceptive stimulation in rats increases their susceptibility to cortical spreading depression",
abstract = "We examined the ability of trigeminal nerve activation to induce cortical spreading depression in rats. Capsaicin was injected into the bilateral plantar or whisker pad for either 4 or 6 days in rats. The number and duration of cortical spreading depressions induced by potassium were significantly increased in animals injected with capsaicin in the bilateral whisker pad compared with animals injected in the bilateral plantar or in controls, while administration of a GABAA receptor agonist decreased these effects. Repetitive nociceptive stimulation of the trigeminal nerve lowers the threshold for the induction of cortical spreading depression by altering GABAergic neuronal activity.",
keywords = "Capsaicin, Cortical spreading depression, GABA, Nociceptive stimulation, Trigeminal nerve",
author = "Haruki Toriumi and Toshihiko Shimizu and Taeko Ebine and Tsubasa Takizawa and Yohei Kayama and Anri Koh and Mamoru Shibata and Norihiro Suzuki",
note = "Funding Information: This research was supported in part by a Health Labor Sciences Research Grant (Research on Region Medical to N. Suzuki; H24-Iryo-Ippan-023) from the Ministry of Health, Labor, and Welfare of Japan and in part by Grants-in-Aid for Scientific Research (grant number 25460726 to T. Shimizu) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. Publisher Copyright: {\textcopyright} 2015 Elsevier Ireland Ltd and the Japan Neuroscience Society.",
year = "2016",
month = may,
day = "1",
doi = "10.1016/j.neures.2015.12.010",
language = "English",
volume = "106",
pages = "74--78",
journal = "Neuroscience Research",
issn = "0168-0102",
publisher = "Elsevier Ireland Ltd",
}