Retrospective analysis of outcome in 63 gallbladder carcinoma patients after radical resection

Hiroshi Yagi, Motohide Shimazu, Shigeyuki Kawachi, Minoru Tanabe, Koichi Aiura, Go Wakabayashi, Masakazu Ueda, Yasutaka Nakamura, Masaki Kitajima

研究成果: Review article査読

32 被引用数 (Scopus)


Background/Purpose: The aim of this study was to evaluate factors influencing outcome in gallbladder carcinoma after radical resection, in order to identify those patients benefiting from radical surgery. Methods: Sixty-three patients (13 pT1, 28 pT2, 14 pT3, and 8 pT4) who underwent surgical resection for gallbladder carcinoma were retrospectively reviewed. Correlations were sought between survival and factors such as the depth of invasion (pT) including the status of infiltration of the hepatoduodenal ligament (pBinf) and liver bed (pHinf), the extent of lymph node metastasis, and other pathologic factors. Results: Multivariate analysis showed that pBinf, pHinf, and lymph node metastasis were significant prognostic factors. We also analyzed survival rates for each operative procedure. There was no difference in survival between patients with or without bile duct resection for lymph node metastasis. The 5-year survival rates of pHinf-negative patients with stage 1B or more advanced disease after gallbladder bed resection or bisegmentectomy 4a,5 versus those without liver resection were 66% and 0%, respectively. Twelve patients survived for more than 5 years after surgery, including one patient undergoing HPD (liver resection with pancreatoduodenectomy) with positive lymph node metastasis; none was pBinf-positive. Conclusions: Several factyors were identified as having prognostic significance for survival in patients with gallbladder carcinomas, and we suggest that radical surgery may be indicated for selected patients with advanced disease.

ジャーナルJournal of Hepato-Biliary-Pancreatic Surgery
出版ステータスPublished - 2006 11月

ASJC Scopus subject areas

  • 外科
  • 肝臓学


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