Ribonuclease inhibitor and angiogenin system regulates cell type–specific global translation

Martina Stillinovic, Mayuresh Anant Sarangdhar, Nicola Andina, Aubry Tardivel, Frédéric Greub, Giuseppe Bombaci, Camille Ansermet, Marco Zatti, Dipanjali Saha, Jieyu Xiong, Takeru Sagae, Mariko Yokogawa, Masanori Osawa, Manfred Heller, Adrian Keogh, Irene Keller, Anne Angelillo-Scherrer, Ramanjaneyulu Allam

研究成果: Article査読


Translation of mRNAs is a fundamental process that occurs in all cell types of multicellular organisms. Conventionally, it has been considered a default step in gene expression, lacking specific regulation. However, recent studies have documented that certain mRNAs exhibit cell type–specific translation. Despite this, it remains unclear whether global translation is controlled in a cell type–specific manner. By using human cell lines and mouse models, we found that deletion of the ribosome-associated protein ribonuclease inhibitor 1 (RNH1) decreases global translation selectively in hematopoietic-origin cells but not in the non–hematopoietic-origin cells. RNH1-mediated cell type–specific translation is mechanistically linked to angiogenin-induced ribosomal biogenesis. Collectively, this study unravels the existence of cell type–specific global translation regulators and highlights the complex translation regulation in vertebrates.

ジャーナルScience Advances
出版ステータスPublished - 2024 5月

ASJC Scopus subject areas

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