TY - JOUR
T1 - Role of ADF/TRX and its inhibitor on the release of major basic protein from human eosinophils
AU - Koyanagi, Hideki
AU - Wakasugi, Naomi
AU - Yoshimatsu, Kentaro
AU - Takashima, Yuichiro
AU - Yodoi, Junji J.
AU - Momoi, Mariko
AU - Suda, Toshio
AU - Kasahara, Tadashi
AU - Yamaguchi, Yuji
PY - 1995
Y1 - 1995
N2 - Adult T cell leukemia-derived factor (ADF)/Thioredoxin (TRX), originally defined as an IL-2 receptor α-chain/p55 inducer, has many cytokine-like activities. We reported that the release of major basic protein (MBP) from mature eosinophils stimulated with cytochalasin B and C5a were augmented after preincubation with recombinant ADF/TRX. The addition of a TRX specific inhibitor, BE40644, suppressed the augmentation of MBP release from mature eosinophils. It is suggested that BE40644 is applicable in allergic diseases associated with eosinophils.
AB - Adult T cell leukemia-derived factor (ADF)/Thioredoxin (TRX), originally defined as an IL-2 receptor α-chain/p55 inducer, has many cytokine-like activities. We reported that the release of major basic protein (MBP) from mature eosinophils stimulated with cytochalasin B and C5a were augmented after preincubation with recombinant ADF/TRX. The addition of a TRX specific inhibitor, BE40644, suppressed the augmentation of MBP release from mature eosinophils. It is suggested that BE40644 is applicable in allergic diseases associated with eosinophils.
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U2 - 10.1006/bbrc.1995.2245
DO - 10.1006/bbrc.1995.2245
M3 - Article
C2 - 7654231
AN - SCOPUS:0029090435
SN - 0006-291X
VL - 213
SP - 1140
EP - 1147
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -