Role of apoptosis in Helicobacter pylori-associated gastric mucosal injury

Hidekazu Suzuki, Hiromasa Ishii

研究成果: Review article査読

29 被引用数 (Scopus)


Apoptosis, a programmed cell death, was ignored, just like Helicobacter pylori, only to reappear recently. However, the number of current publications dealing with apoptosis or H. pylori has increased exponentially. Although gastric epithelial apoptosis is a programmed physiological event in the superficial aspect of the mucosa and is important for healthy cell turnover, H. pylori infection reportedly promotes such a cell death sequence. Because apoptosis regulates the cycle of cell turnover in balance with proliferation, dysregulation of apoptosis or proliferation evoked by H. pylori colonization would be linked to the gastric carcinogenesis. In other words, a reduced level of apoptosis could contribute to the generation of gastric cancer. Herein, we review apoptosis as well as its associated pathological events, such as hyperproliferation, in H. pylori-colonized gastric mucosa. (C) 2000 Blackwell Science Asia Pty Ltd.

ジャーナルJournal of Gastroenterology and Hepatology (Australia)
出版ステータスPublished - 2000

ASJC Scopus subject areas

  • 肝臓学
  • 消化器病学


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