TY - JOUR
T1 - Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis
AU - Kato, Shingo
AU - Tsuzuki, Yoshikazu
AU - Hokari, Ryota
AU - Okada, Yoshikiyo
AU - Miyazaki, Junichi
AU - Matsuzaki, Koji
AU - Iwai, Atsuhiro
AU - Kawaguchi, Atsushi
AU - Nagao, Shigeaki
AU - Itoh, Kazuro
AU - Suzuki, Hidekazu
AU - Nabeshima, Toshitaka
AU - Miura, Soichiro
N1 - Funding Information:
This study was supported in part by grants from National Defense Medical College and Keio University School of Medicine. This study was also supported by grants from the Smoking Research Foundation and the Food Science Institute Foundation.
PY - 2005/4
Y1 - 2005/4
N2 - Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.
AB - Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.
KW - Adhesion molecule
KW - Colitis
KW - Dextran sulfate sodium
KW - Nociceptin/orphanin FQ
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U2 - 10.1016/j.jneuroim.2004.12.006
DO - 10.1016/j.jneuroim.2004.12.006
M3 - Article
C2 - 15748940
AN - SCOPUS:20044374866
SN - 0165-5728
VL - 161
SP - 21
EP - 28
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -