@article{bad351a4f64748169e84d80e68d67f95,
title = "Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells",
abstract = "Regulatory T (Treg) cells are an essential cell subset for the maintenance of immune homeostasis. Treg cells are characterized by a distinct pattern of gene expression, including the upregulation of immune-suppressive genes and the silencing of inflammatory genes. The molecular mechanisms involved in the development and maintenance of Tregs have been extensively investigated. We have identified essential transcription factors NR4a and Smad2/3 in the development of thymic Tregs and induced Tregs, respectively. This article reviews the roles of transcription factors in the differentiation, maintenance, and function of Treg cells.",
keywords = "Clostridium species, DNA methylation, Foxp3, Regulatory T cell, TGF-β, Transcription factors",
author = "Takashi Sekiya and Hiroko Nakatsukasa and Qianjin Lu and Akihiko Yoshimura",
note = "Funding Information: This work was supported by JSPS KAKENHI Grant-in-Aid for Young Scientists (A) and (S) No. 25221305 , Advanced Research & Development Programs for Medical Innovation (AMED-CREST), the Takeda Science Foundation , the Uehara Memorial Foundation , the Mochida Memorial Foundation for Medical and Pharmaceutical Research , the Kanae Foundation , and the SENSHIN Medical Research Foundation , Keio Gijuku Academic Developmental Funds . Publisher Copyright: {\textcopyright} 2016 Institut Pasteur Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2016",
month = jun,
day = "1",
doi = "10.1016/j.micinf.2016.02.004",
language = "English",
volume = "18",
pages = "378--386",
journal = "Microbes and Infection",
issn = "1286-4579",
publisher = "Elsevier Masson SAS",
number = "6",
}
