Salvage surgery for a super-responder by gefitinib therapy for advanced lung cancer

Kohei Hashimoto, Hirohisa Horinouchi, Takashi Ohtsuka, Mitsutomo Kohno, Yotaro Izumi, Yuichiro Hayashi, Hiroaki Nomori

研究成果: Article査読

16 被引用数 (Scopus)


Salvage surgery after gefitinib therapy in a 66-year-old female with cT4N1M1a lung adenocarcinoma in the right middle lobe, which had gene mutation of epidermal growth factor receptor, is presented. The patient had bulky hilar lymph nodes, pleural dissemination, and pulmonary metastases in the ipsilateral lobes. After 3 courses of chemotherapy, the patient was treated with gefitinib, resulting in partial response, i.e. only the primary tumor and the middle lobe atelectasis remained. We performed the middle lobe lobectomy aimed at local control and pathological confirmation of the remaining tumor. Because the hilum of the middle lobe was occupied with scar tissue, its pulmonary vein had to be cut within the pericardium and its pulmonary artery and bronchus had to be transected simultaneously with a stapler. Pathological stage was yp-T2aN0N0 with Ef 2. For salvage surgery after good response to gefitinib therapy, it should be taken care to expose pulmonary vessels.

ジャーナルGeneral thoracic and cardiovascular surgery
出版ステータスPublished - 2012 12月 1

ASJC Scopus subject areas

  • 外科
  • 呼吸器内科
  • 循環器および心血管医学


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