Self-assembly behaviours of primitive and modern lipid membrane solutions: A coarse-grained molecular simulation study

Noriyoshi Arai, Yuki Yoshimoto, Kenji Yasuoka, Toshikazu Ebisuzaki

研究成果: Article査読

29 被引用数 (Scopus)

抄録

Researchers have studied the origin of life and the process of evolution on early Earth for decades. However, we lack a comprehensive understanding of biogenesis, because there are many stages in the formation and growth of the first cell. We investigate the self-replication processes of coacervate protocells using computer simulations of single-chain lipid and phospholipid aqueous mixtures. Based on a morphological phase diagram, we develop a model of prebiotic self-replication driven by only environmental factors (i.e. temperature and lipid concentrations) without any external force. Moreover, we investigate high concentration structures during the process of self-replication. These structures have an advantage in fusion and repair of cell membranes. Therefore, lipid hot spots may have existed in primordial soup.

本文言語English
ページ(範囲)19426-19432
ページ数7
ジャーナルPhysical Chemistry Chemical Physics
18
28
DOI
出版ステータスPublished - 2016

ASJC Scopus subject areas

  • 物理学および天文学一般
  • 物理化学および理論化学

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