TY - JOUR
T1 - Self-rated cognitive functions following chemotherapy in patients with breast cancer
T2 - A 6-month prospective study
AU - Kitahata, Ryosuke
AU - Nakajima, Shinichiro
AU - Uchida, Hiroyuki
AU - Hayashida, Tetsu
AU - Takahashi, Maiko
AU - Nio, Shintaro
AU - Hirano, Jinichi
AU - Nagaoka, Maki
AU - Suzuki, Takefumi
AU - Jinno, Hiromitsu
AU - Kitagawa, Yuko
AU - Mimura, Masaru
N1 - Funding Information:
Dr Ryosuke Kitahata has received Inokashira Hospital Research Grant within the past 3 years. Dr Shinichiro Nakajima has received fellowship grants from Canadian Institute of Health Research (CIHR), research support from Japan Society for the Promotion of Science, and manuscript fees or speaker’s honoraria from Dainippon Sumitomo Pharma and Yoshitomi Yakuhin within the past 3 years. Dr Hiroyuki Uchida has received grants from Astellas Pharmaceutical, Eisai, Otsuka Pharmaceutical, Shionogi, Dainippon-Sumitomo Pharma, Eli Lilly, Mochida Pharmaceutical, Meiji-Seika Pharma, and Yoshitomi Yakuhin and speaker’s honoraria from Otsuka Pharmaceutical, Eli Lilly, Shionogi, Pfizer, Yoshi-tomi Yakuhin, Dainippon-Sumitomo Pharma, Meiji-Seika Pharma, MSD, and Janssen Pharmaceutical within the past 3 years. Dr Tetsu Hayashida has received grants and/or speaker’s honoraria from Daiichi Sankyo, Eisai, Novartis Pharma, Takeda within the past 3 years. Dr Maiko Takahashi reports no conflicts of interest in this work. Dr Shintaro Nio has received speaker’s honoraria from Astellas, Dainippon Sumitomo, Eisai, Eli Lilly, GlaxoSmithKline, Janssen Pharmaceutical, Mitsubishi Tanabe Pharma, Mochida Pharmaceutical, Otsuka Pharmaceutical, Pfizer, Shionogi, Takeda, and Yoshitomi Yakuhin within the past 3 years. Dr Jinichi Hirano has received grants from Eli Lilly and speaker’s honoraria from Otsuka Pharmaceutical and Yoshitomi Yakuhin within the past 3 years. Mrs Maki Nagaoka has received Inokashira Hospital Research Grant within the past 3 years. Dr Takefumi Suzuki has received manuscript or speaker’s honoraria from Astellas, Dainippon Sumitomo, Eli Lilly, Elsevier Japan, Janssen, Meiji Seika, Novartis, Otsuka, and Wiely Japan within the past 3 years. Dr Hiromitsu Jinno has received grants and/or speaker’s honoraria from AstraZeneca, Pfizer, Chugai, Taiho, Novartis Pharma, and Kyowa Kirin within the past 3 years. Dr Yuko Kitagawa has received grants and/or speaker’s honoraria from Astellas Pharmaceutical, Daiichi Sankyo, Dainippon-Sumitomo Pharma, Eisai, Eli Lilly, GlaxoSmithKline, Novartis Pharma, Pfizer, Shionogi, Takeda, Shionogi, and Otsuka Pharmaceutical within the past 3 years. Dr Masaru Mimura has received grants and/or speaker’s honoraria from Asahi Kasei Pharma, Astellas Pharmaceutical, Daiichi Sankyo, Dainippon-Sumitomo Pharma, Eisai, Eli Lilly, GlaxoSmithKline, Janssen Pharmaceutical, Meiji-Seika Pharma, Mochida Pharmaceutical, MSD, Novar-tis Pharma, Otsuka Pharmaceutical, Pfizer, Shionogi, Takeda, Tanabe Mitsubishi Pharma, and Yoshitomi Yakuhin within the past 3 years.
Publisher Copyright:
© 2017 Kitahata et al.
PY - 2017/10/3
Y1 - 2017/10/3
N2 - Purpose: The purpose of the study was to evaluate subjective (self-rated), family-rated, and objective (researcher-rated) cognitive functions in patients with breast cancer after chemotherapy. Method: We conducted a prospective study to trace self-rated cognitive functions in 30 patients with breast cancer at the completion of chemotherapy (T0) and 6 months later (T1). Subjective cognitive functions were assessed with Cognitive Failures Questionnaire (CFQ), Dysexecutive Questionnaire (DEX-S), and Everyday Memory Checklist (EMC-S) for attention, executive function, and episodic memory, respectively. Their family members also completed DEX-I and EMC-I for executive function and episodic memory, respectively. We also examined objective cognitive functions. Self-rated cognitive functions were compared with the normative data. They were compared between T0 and T1. We calculated correlation coefficients between self-rated and other cognitive functions. Results: At T0, 6 (20.0%) and 2 (6.7%) participants showed higher DEX-S and EMC-S scores than the normative data, respectively, while no participant had abnormal CFQ scores. At T1, DEX-S and EMC-S scores were normalized in 3 (50.0%) and 2 (100.0%) participants, respectively. No participant showed increases in CFQ scores. No changes were found in objective cognitive functions from T0 to T1. DEX-S and DEX-I or EMC-S and EMC-I scores were correlated at both T0 and T1, which did not survive multiple corrections. There was no association between subjective and objective cognitive functions. Conclusion: Impairments in subjective cognition may be transient after chemotherapy in patients with breast cancer. Furthermore, patients and their families appear to share similar prospects on their cognitive functions.
AB - Purpose: The purpose of the study was to evaluate subjective (self-rated), family-rated, and objective (researcher-rated) cognitive functions in patients with breast cancer after chemotherapy. Method: We conducted a prospective study to trace self-rated cognitive functions in 30 patients with breast cancer at the completion of chemotherapy (T0) and 6 months later (T1). Subjective cognitive functions were assessed with Cognitive Failures Questionnaire (CFQ), Dysexecutive Questionnaire (DEX-S), and Everyday Memory Checklist (EMC-S) for attention, executive function, and episodic memory, respectively. Their family members also completed DEX-I and EMC-I for executive function and episodic memory, respectively. We also examined objective cognitive functions. Self-rated cognitive functions were compared with the normative data. They were compared between T0 and T1. We calculated correlation coefficients between self-rated and other cognitive functions. Results: At T0, 6 (20.0%) and 2 (6.7%) participants showed higher DEX-S and EMC-S scores than the normative data, respectively, while no participant had abnormal CFQ scores. At T1, DEX-S and EMC-S scores were normalized in 3 (50.0%) and 2 (100.0%) participants, respectively. No participant showed increases in CFQ scores. No changes were found in objective cognitive functions from T0 to T1. DEX-S and DEX-I or EMC-S and EMC-I scores were correlated at both T0 and T1, which did not survive multiple corrections. There was no association between subjective and objective cognitive functions. Conclusion: Impairments in subjective cognition may be transient after chemotherapy in patients with breast cancer. Furthermore, patients and their families appear to share similar prospects on their cognitive functions.
KW - Breast cancer
KW - Chemotherapy
KW - Subjective cognitive functions
UR - http://www.scopus.com/inward/record.url?scp=85031126583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85031126583&partnerID=8YFLogxK
U2 - 10.2147/NDT.S141408
DO - 10.2147/NDT.S141408
M3 - Article
AN - SCOPUS:85031126583
SN - 1176-6328
VL - 13
SP - 2489
EP - 2496
JO - Neuropsychiatric Disease and Treatment
JF - Neuropsychiatric Disease and Treatment
ER -
