@article{0edbdfccfab14010bd553f0573621386,
title = "Semisynthesis of prunetin, a bioactive O-methylated isoflavone from naringenin, by the sequential deacetylation of chalcone intermediates and oxidative rearrangement",
abstract = "Prunetin (4′,5-dihydroxy-7-methoxyisoflavone) was semisynthesized in 8 steps from readily available naringenin in 26% total yield. The key reaction was chemoenzymatic sequential deacetylation to 6′-acetoxy-2′,4″-dihydroxy-4′-methoxychalcone, the in situ-formed precursor for thallium(III) nitrate-mediated oxidative rearrangement. ",
keywords = "O-methylated isoflavone, chalcone, deacetylation, naringenin, oxidative rearrangement",
author = "Takeshi Sugai and Kengo Hanaya and Shuhei Higashibayashi",
note = "Funding Information: This work was supported by JSPS KAKENHI (19K05849) to T.S. and is gratefully acknowledged with thanks. Publisher Copyright: {\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.",
year = "2021",
month = jan,
day = "1",
doi = "10.1093/bbb/zbaa021",
language = "English",
volume = "85",
pages = "143--147",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "1",
}