Sentinel node navigation surgery in early-stage esophageal cancer

Hiroya Takeuchi, Hirofumi Kawakubo, Flavio Takeda, Tai Omori, Yuko Kitagawa

研究成果: Review article査読

18 被引用数 (Scopus)


The sentinel node (SN) concept has revolutionized the surgical staging of both melanoma and breast cancer over the past two decades. However, the validity of the SN hypothesis has been controversial for esophageal cancer, because SN mapping for esophageal cancer is technically complicated, and the number of early-stage esophageal cancer is very limited. Nevertheless previous studies nicely demonstrated that SN mapping may be feasible in patients with earlystage esophageal cancer. Transthoracic extended esophagectomy with three-field radical lymph node dissection has been recognized as a curative procedure for thoracic esophageal cancer in Japan. However, uniform application of this highly invasive procedure might increase the morbidity and markedly reduce the quality of life (QOL) after surgery. Although further accumulation of evidence based on multicenter clinical trials using a standard protocol is needed, SN mapping and SN navigation surgery would provide significant information to perform individualized selective lymphadenectomy which might reduce the morbidity and retain the patients' QOL. In addition, technical innovation including the development of new tracers is expected to confirm the accuracy and reliability of SN mapping in esophageal cancer.

ジャーナルAnnals of Thoracic and Cardiovascular Surgery
出版ステータスPublished - 2012

ASJC Scopus subject areas

  • 外科
  • 呼吸器内科
  • 循環器および心血管医学
  • 消化器病学


「Sentinel node navigation surgery in early-stage esophageal cancer」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。