抄録
Diabetes mellitus and hypertension frequently occur in the same individual, based upon 'insulin resistance', which is caused by obesity and impairment of secretion of several adipocyte-derived hormones(adipocytokines), including leptin and adiponectin. Insulin resistance and activation of tissue renin-angiotensin system mutually affect each other to promote diabetes mellitus/hypertension and their complications. Especially, renin-angiotensin system in the adipose tissue modulate adipocyte differentiation and adipose tissue mass. Vascular renin-angiotensin system causes endothelial dysfunction and promotes inflammatory process to accelerate atherosclerosis. Blockade of renin-angiotensin system is reasonable for prevention and suppression of diabetes mellitus/hypertension and their complications.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 1145-1153 |
| ページ数 | 9 |
| ジャーナル | Nippon rinsho. Japanese journal of clinical medicine |
| 巻 | 61 |
| 号 | 7 |
| 出版ステータス | Published - 2003 7月 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 医学（全般）
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
