抄録
This study was undertaken to examine the prevalence of Actinobacillus actinomycetemcomitans, its serotype distribution and the serum immune responses against its surface antigens in 41 Japanese patients with adult periodontitis. The dominant A. actinomycetemcomitans serotype isolated was serotype c. Immunoblot analysis of 3 serotypes of A. actinomycetemcomitans‐sonicated antigens and the patient sera revealed that the reactivities with serotype c were the most frequent and that heat‐stable surface serotype‐specific antigen appeared to be immunodominanl. Elevated serum immunoglobulin G titers to extracted lipopolysaccharide and fimbriae antigen of A. actinomycetemcomitans were noted for the patient sera by enzyme‐linked immunosorbent assay. High serum immunoglobulin G tilers to the fimbriae antigen detected in patients without cultivable A. actinomycetemcomitans suggested Ihe possibilily that the clicked antibody to the antigen played a role in eliminating A. actinomycetemcomitans from the periodontal lesions.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 146-153 |
| ページ数 | 8 |
| ジャーナル | Oral microbiology and immunology |
| 巻 | 8 |
| 号 | 3 |
| DOI | |
| 出版ステータス | Published - 1993 6月 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 微生物学
- 免疫学
- 歯科学（全般）
- 微生物学（医療）