@article{684eabc044e84875a94da62d7fbcdeef,
title = "Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures",
abstract = "In this article, Ieda and colleagues showed that a soft matrix, which is comparable with native myocardium, efficiently promoted cardiac reprogramming. This soft matrix enhanced cardiac reprogramming via inhibition of integrin, Rho/ROCK, actomyosin, and YAP/TAZ signaling and subsequent suppression of fibroblast programs, which were activated on conventional rigid substrates, thus demonstrating that mechanotransduction plays a critical role in cardiac reprogramming.",
keywords = "YAP/TAZ, cardiac reprogramming, mechanotransduction, myocardium, soft matrix",
author = "Shota Kurotsu and Taketaro Sadahiro and Ryo Fujita and Hidenori Tani and Hiroyuki Yamakawa and Fumiya Tamura and Mari Isomi and Hidenori Kojima and Yu Yamada and Yuto Abe and Yoshiko Murakata and Tatsuya Akiyama and Naoto Muraoka and Ichiro Harada and Takeshi Suzuki and Keiichi Fukuda and Masaki Ieda",
note = "Funding Information: M. Ieda was supported by research grants from the Advanced Research & Development Programs for Medical Innovation (solo-type; JP18gm5810002), the Research Center Network for Realization of Regenerative Medicine (JP20bm0704030), the Japan Agency for Medical Research and Development (AMED), the Japan Society for the Promotion of Science (JSPS; 19K22613), and the Takeda Science Foundation. S.K. was supported by a research grant from the Japan Society for the Promotion of Science (JSPS; 17J06637). T. Sadahiro was supported by research grants from JSPS (18K08114), SENSHIN Medical Research Foundation, The Uehara Memorial Foundation, Mochida Memorial Foundation, and The Kanae Foundation. R.F. was supported by Leading Initiative for Excellent Young Researchers (MEXT), H.Y. was supported by The Vehicle Racing Commemorative Foundation and Japan Society for the Promotion of Science (JSPS; 18K08047). Funding Information: M. Ieda was supported by research grants from the Advanced Research & Development Programs for Medical Innovation (solo-type; JP18gm5810002 ), the Research Center Network for Realization of Regenerative Medicine ( JP20bm0704030 ), the Japan Agency for Medical Research and Development (AMED), the Japan Society for the Promotion of Science (JSPS; 19K22613 ), and the Takeda Science Foundation . S.K. was supported by a research grant from the Japan Society for the Promotion of Science (JSPS; 17J06637 ). T. Sadahiro was supported by research grants from JSPS ( 18K08114 ), SENSHIN Medical Research Foundation , The Uehara Memorial Foundation , Mochida Memorial Foundation , and The Kanae Foundation . R.F. was supported by Leading Initiative for Excellent Young Researchers ( MEXT ), H.Y. was supported by The Vehicle Racing Commemorative Foundation and Japan Society for the Promotion of Science (JSPS; 18K08047 ). Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = sep,
day = "8",
doi = "10.1016/j.stemcr.2020.07.022",
language = "English",
volume = "15",
pages = "612--628",
journal = "Stem cell reports",
issn = "2213-6711",
publisher = "Cell Press",
number = "3",
}