@article{689f749f4e4d47df968b7121375645e2,
title = "Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1",
abstract = "Sox21, a high-mobility group box transcription factor, is expressed throughout the immature neural stem/progenitor population in ventricular zone but not in the cortical plate in embryonic mouse brain and its expression is restricted to the subventricular zone in the adult brain. In undifferentiated PC12 cells, endogenous Sox21 expression is detected but its expression ceases during the nerve growth factor (NGF)-induced neuronal differentiation. Overexpression of Sox21 results in a substantial repression of NGF-induced neurite outgrowth in PC12 cells. Further, we biochemically identified a Sox21-associating protein, Y-box binding protein 1 which not only binds to Sox21 but also partially restores NGF-induced neurite outgrowth of PC12 cells inhibited by Sox21. These results suggest that Sox21 is a repressor of neuronal differentiation in the developing nervous system.",
keywords = "Development, Neural stem cells, Neurite outgrowth, Sox21, Transcription factor, Y-box binding protein 1",
author = "Hiroyuki Ohba and Tatsuyuki Chiyoda and Emmy Endo and Masato Yano and Yoshika Hayakawa and Masanori Sakaguchi and Darnell, {Robert B.} and Okano, {Hirotaka J.} and Hideyuki Okano",
note = "Funding Information: We thank T. Kitamura for pMYs vector and Plat-E. We thank our colleagues, particularly W. Akamatsu, S. Shibata, H. Tada, T. Kojima, for help, encouragement, and advice. This work was supported by grants from the Japanese Ministry of Education, Sports and Culture, CREST-JST, National Grant-in-Aid for the Establishment of High-Tech Research Center in a Private University, Keio Medical Association (H.J.O and H.O), a General Clinical Research Center grant (M01-RR00102) from the National Center for Research Resources at the National Institutes of Health, and NIH RO1 CA85784-01A2 (R.B.D), a grant from the 21st century COE program of the Ministry of Education, Science and Culture of Japan to Keio University.",
year = "2004",
month = apr,
day = "1",
doi = "10.1016/j.neulet.2004.01.026",
language = "English",
volume = "358",
pages = "157--160",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",
}