Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co- glycolic acid nano-fiber scaffold

Koshiro Sonomoto; Kunihiro Yamaoka; Hiroaki Kaneko; Kaoru Yamagata; Kei Sakata; Xiangmei Zhang; Masahiro Kondo; Yukichi Zenke; Ken Sabanai; Shingo Nakayamada; Akinori Sakai; Yoshiya Tanaka

doi:10.1371/journal.pone.0153231

Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co- glycolic acid nano-fiber scaffold

Koshiro Sonomoto
, Kunihiro Yamaoka
, Hiroaki Kaneko
, Kaoru Yamagata
, Kei Sakata
, Xiangmei Zhang
, Masahiro Kondo
, Yukichi Zenke
, Ken Sabanai
, Shingo Nakayamada
, Akinori Sakai
, Yoshiya Tanaka

内科学

研究成果: Article › 査読

55 被引用数 (Scopus)

抄録

Mesenchymal stem cells (MSCs) have immunosuppressive activity and can differentiate into bone and cartilage; and thus seem ideal for treatment of rheumatoid arthritis (RA). Here, we investigated the osteogenesis and chondrogenesis potentials of MSCs seeded onto nano-fiber scaffolds (NFs) in vitro and possible use for the repair of RA-affected joints.

本文言語	English
論文番号	e0153231
ジャーナル	PloS one
巻	11
号	4
DOI	https://doi.org/10.1371/journal.pone.0153231
出版ステータス	Published - 2016 4月

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10.1371/journal.pone.0153231

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title = "Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co- glycolic acid nano-fiber scaffold",

abstract = "Mesenchymal stem cells (MSCs) have immunosuppressive activity and can differentiate into bone and cartilage; and thus seem ideal for treatment of rheumatoid arthritis (RA). Here, we investigated the osteogenesis and chondrogenesis potentials of MSCs seeded onto nano-fiber scaffolds (NFs) in vitro and possible use for the repair of RA-affected joints.",

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AU - Sonomoto, Koshiro

AU - Yamaoka, Kunihiro

AU - Kaneko, Hiroaki

AU - Yamagata, Kaoru

AU - Sakata, Kei

AU - Zhang, Xiangmei

AU - Kondo, Masahiro

AU - Zenke, Yukichi

AU - Sabanai, Ken

AU - Nakayamada, Shingo

AU - Sakai, Akinori

AU - Tanaka, Yoshiya

N1 - Publisher Copyright: © 2016 Sonomoto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2016/4

Y1 - 2016/4

N2 - Mesenchymal stem cells (MSCs) have immunosuppressive activity and can differentiate into bone and cartilage; and thus seem ideal for treatment of rheumatoid arthritis (RA). Here, we investigated the osteogenesis and chondrogenesis potentials of MSCs seeded onto nano-fiber scaffolds (NFs) in vitro and possible use for the repair of RA-affected joints.

AB - Mesenchymal stem cells (MSCs) have immunosuppressive activity and can differentiate into bone and cartilage; and thus seem ideal for treatment of rheumatoid arthritis (RA). Here, we investigated the osteogenesis and chondrogenesis potentials of MSCs seeded onto nano-fiber scaffolds (NFs) in vitro and possible use for the repair of RA-affected joints.

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DO - 10.1371/journal.pone.0153231

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SN - 1932-6203

VL - 11

JO - PloS one

JF - PloS one

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Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co- glycolic acid nano-fiber scaffold

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