Stem cell theory for the pathogenesis of endometriosis

Tetsuo Maruyama, Yasunori Yoshimura

研究成果: Article査読

45 被引用数 (Scopus)

抄録

Proposed hypothetical causes of endometriosis include retrograde menstruation, lymphatic and vascular metastasis, iatrogenic direct implantation, coelomic metaplasia, embryonic rest, and mesenchymal cell differentiation (induction). Each theory, individually, fails to account for all types of endometriotic lesions, thereby implicating combined and/or type-specific mechanisms. Recent evidence supports the presence of endometrial stem/progenitor cells and their possible involvement in eutopic endometrial regeneration and differentiation. Thus an additional novel mechanism for the origin of endometriotic lesions is that they arise from ectopic endometrial stem/progenitor cells.

本文言語English
ページ(範囲)2754-2763
ページ数10
ジャーナルFrontiers in Bioscience - Elite
4 E
8
出版ステータスPublished - 2012 6月 1

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学一般
  • 免疫学および微生物学一般

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