Stereospecific Incorporation of Hydrogen from Reduced Nicotinamide Adenine Dinucleotide Phosphate in Hydrogenation of (—)-Dehydrogriseofulvin to (+)-Griseofulvin by a Partially Purified Enzyme System of Streptomyces cinereocrocatus

Taiko Oda; Yoshihiro Sato

doi:10.1248/cpb.34.4635

Stereospecific Incorporation of Hydrogen from Reduced Nicotinamide Adenine Dinucleotide Phosphate in Hydrogenation of (—)-Dehydrogriseofulvin to (+)-Griseofulvin by a Partially Purified Enzyme System of Streptomyces cinereocrocatus

Taiko Oda, Yoshihiro Sato

薬学科

研究成果: Article › 査読

5 被引用数 (Scopus)

抄録

The stereochemistry of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent hydrogenation was investigated by the conversion of (—)-dehydrogriseofulvin (1) to (+)-griseofulvin (2a) by the use of a partially purified enzyme system of Streptomyces cinereocrocatus in the presence of (4R)- or (4S)-[4-²H₁]NADPH. The results of 270 MHz proton nuclear magnetic resonance spectroscopy indicated that the origin of the 6’α-hydrogen of 2a is a hydride ion donated by pro-4R-hydrogen of NADPH.

本文言語	English
ページ（範囲）	4635-4640
ページ数	6
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	34
号	11
DOI	https://doi.org/10.1248/cpb.34.4635
出版ステータス	Published - 1986 1月 1

ASJC Scopus subject areas

化学 (全般)
創薬

文献へのアクセス

10.1248/cpb.34.4635

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「Stereospecific Incorporation of Hydrogen from Reduced Nicotinamide Adenine Dinucleotide Phosphate in Hydrogenation of (—)-Dehydrogriseofulvin to (+)-Griseofulvin by a Partially Purified Enzyme System of Streptomyces cinereocrocatus」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Stereospecific Incorporation of Hydrogen from Reduced Nicotinamide Adenine Dinucleotide Phosphate in Hydrogenation of (—)-Dehydrogriseofulvin to (+)-Griseofulvin by a Partially Purified Enzyme System of Streptomyces cinereocrocatus. / Oda, Taiko; Sato, Yoshihiro.
In: Chemical and Pharmaceutical Bulletin, Vol. 34, No. 11, 01.01.1986, p. 4635-4640.

研究成果: Article › 査読

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title = "Stereospecific Incorporation of Hydrogen from Reduced Nicotinamide Adenine Dinucleotide Phosphate in Hydrogenation of (—)-Dehydrogriseofulvin to (+)-Griseofulvin by a Partially Purified Enzyme System of Streptomyces cinereocrocatus",

abstract = "The stereochemistry of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent hydrogenation was investigated by the conversion of (—)-dehydrogriseofulvin (1) to (+)-griseofulvin (2a) by the use of a partially purified enzyme system of Streptomyces cinereocrocatus in the presence of (4R)- or (4S)-[4-2H1]NADPH. The results of 270 MHz proton nuclear magnetic resonance spectroscopy indicated that the origin of the 6{\textquoteright}α-hydrogen of 2a is a hydride ion donated by pro-4R-hydrogen of NADPH.",

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