Structural and biological characterization of Fe3O4-loaded spherical and tubular liposomes for use in drug delivery systems

Mina Sakuragi, Kazuaki Taguchi, Katsuki Kusakabe

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Magnetic liposomes containing Fe3O4 nanoparticles were prepared using colipids [1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine (DC8,9PC)] and mixtures of the colipids with an anionic lipid [1,2-dioleoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt (DOPG)] or a cationic lipid [cetyltrimethylammonium bromide (CTAB)]. Transmission electron microscopy (TEM) and small-angle X-ray scattering (SAXS) analysis showed that the magnetic liposomes containing DC8,9PC and DOPC were tubular and spherical in structure, respectively. The effects of an external magnetic field and the structure of the liposomes on cellular association were investigated. The external magnetic field increased cellular association and uptake levels independent of the structure both in vitro and in vivo. Although the level of in vitro cellular association for the tubular liposomes was higher than that for the spherical liposomes, there was no significant difference in the level of in vivo uptake of fluorescent Fe3O4 nanoparticles in the mouse liver. Finally, the magnetic liposomes were found to be biocompatible by haematological and serum chemical analyses.

本文言語English
論文番号055002
ジャーナルJapanese journal of applied physics
56
5
DOI
出版ステータスPublished - 2017 5月
外部発表はい

ASJC Scopus subject areas

  • 工学一般
  • 物理学および天文学一般

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