TY - JOUR
T1 - Suppression of infliximab antibody levels by azathioprine in patients with rheumatoid arthritis
AU - Aomori, Tohru
AU - Tsuchiya, A.
AU - Suzuki, S.
AU - Jibiki, A.
AU - Ootsuka, Naoko
AU - Ishioka, E.
AU - Kaneko, Y.
AU - Takeuchi, Tsutomu
AU - Nakamura, T.
N1 - Funding Information:
This work was supported by JSPS KAKENHI [Grant Number 15K18933] and The Uehara Memorial Foundation.
Publisher Copyright:
© 2017, Govi-Verlag Pharmazeutischer Verlag GmbH. All rights reserved.
PY - 2017
Y1 - 2017
N2 - In rheumatoid arthritis (RA) treatment, the concomitant use of methotrexate has been shown to reduce the incidence of antibodies to infliximab (ATI), on the other hand, it is unclear whether azathioprine can reduce ATI production. We enrolled a total of 10 Japanese adult patients with RA who were treated with infliximab concomitantly with methotrexate or azathioprine. Serum concentrations of infliximab and ATI of these patients were measured. The mean serum infliximab concentrations was 1.6±1.3 μg/ml in patients with methotrexate and 1.0±0.5 μg/ml in patients with azathioprine. Serum ATI concentrations were below the limit of quantitation in 4 of 5 patients in each group. The results from the present study suggest that azathioprine suppresses ATI production.
AB - In rheumatoid arthritis (RA) treatment, the concomitant use of methotrexate has been shown to reduce the incidence of antibodies to infliximab (ATI), on the other hand, it is unclear whether azathioprine can reduce ATI production. We enrolled a total of 10 Japanese adult patients with RA who were treated with infliximab concomitantly with methotrexate or azathioprine. Serum concentrations of infliximab and ATI of these patients were measured. The mean serum infliximab concentrations was 1.6±1.3 μg/ml in patients with methotrexate and 1.0±0.5 μg/ml in patients with azathioprine. Serum ATI concentrations were below the limit of quantitation in 4 of 5 patients in each group. The results from the present study suggest that azathioprine suppresses ATI production.
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U2 - 10.1691/ph.2017.6791
DO - 10.1691/ph.2017.6791
M3 - Article
C2 - 29441860
AN - SCOPUS:85013345313
SN - 0031-7144
VL - 72
SP - 95
EP - 97
JO - Pharmazie
JF - Pharmazie
IS - 2
ER -