@article{b7dad3955f84477ba52839c0dd9cbc96,
title = "Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells",
abstract = "The present study is the first to demonstrate the synergetic effect of statins (atorvastatin and simvastatin) and gamma-tocotrienol (γ-T3) on human malignant mesothelioma (MM). Statin + γ-T3 combinations induced greater cell growth inhibition more than each single treatment via inhibition of mevalonate pathway, a well-known target of both γ-T3 and statins. γ-T3 was necessary for endoplasmic reticulum stress markers CHOP and GRP78, whereas an intrinsic apoptotic marker, caspase 3 activation was induced only in the presence of statins. Overall, the combination of γ-T3 and statins could be useful for MM therapy and functions in a complementary style.",
keywords = "Apoptosis, Gamma tocotrienol, Mesothelioma, Mevalonate pathway, Statin",
author = "Guligena Tuerdi and Saki Ichinomiya and Hiromi Sato and Sana Siddig and Eriko Suwa and Hiroki Iwata and Tomohiro Yano and Koichi Ueno",
note = "Funding Information: We thank Dr. Yuji Nakayama (Kyoto Pharmaceutical University) and Dr. Yasunori Fukumoto (Chiba University) for their assistance in performing the cell cycle analysis. This study was partially supported by a Grant-in-Aid for Young Scientists (B) #24790529 from the Japan Society for the Promotion of Sciences , Special Funds for Education and Research (Development of SPECT probes for Pharmaceutical Innovation) from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and a research grant from the Takeda Science Foundation. The funding agency had no role in the study design; in the collection, analysis, or interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication.",
year = "2013",
month = oct,
day = "1",
doi = "10.1016/j.canlet.2013.07.015",
language = "English",
volume = "339",
pages = "116--127",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",
}
