Synthesis and biological activity of ester and ether analogues of α-galactosylceramide (KRN7000)

Masao Shiozaki, Takuya Tashiro, Hiroyuki Koshino, Ryusuke Nakagawa, Sayo Inoue, Tomokuni Shigeura, Hiroshi Watarai, Masaru Taniguchi, Kenji Mori

研究成果: Article査読

38 被引用数 (Scopus)

抄録

These three ester analogues showed activity for IFNγ, and IL-4 production of iNKT cells. α-Galactosylceramide (αGalCer, KRN7000) has been identified as a modulator of immunological processes through its capacity to bind iNKT cells mediated by CD1d molecules. Some analogues in while the amide group in αGalCer is replaced with ester or ether groups were synthesized from d-arabinitol or l-ribose to evaluate their ability to activate iNKT cells. Ester analogues 30a, 31a, and 61 showed activity for IFNγ and IL-4 production of iNKT cells, while ether (31b) and 4-methoxy ester (76) analogues of α-galactosylceramide were not active for iNKT cells.

本文言語English
ページ(範囲)1663-1684
ページ数22
ジャーナルCarbohydrate Research
345
12
DOI
出版ステータスPublished - 2010 8月 16
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 生化学
  • 有機化学

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