Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

Yuichi Ishikawa; Miyuki Tachibana; Chino Matsui; Rika Obata; Kazuo Umezawa; Shigeru Nishiyama

doi:10.1016/j.bmcl.2009.01.107

Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

Yuichi Ishikawa
, Miyuki Tachibana
, Chino Matsui
, Rika Obata
, Kazuo Umezawa
, Shigeru Nishiyama

文学部

研究成果: Article › 査読

29 被引用数 (Scopus)

抄録

Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.

本文言語	English
ページ（範囲）	1726-1728
ページ数	3
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	19
号	6
DOI	https://doi.org/10.1016/j.bmcl.2009.01.107
出版ステータス	Published - 2009 3月 15

ASJC Scopus subject areas

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

文献へのアクセス

10.1016/j.bmcl.2009.01.107

他のファイルとリンク

引用スタイル

@article{33ff16ced79948c7bd1edf61f47042cb,

title = "Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB",

abstract = "Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.",

keywords = "9-Methylstreptimidone, Inhibitor, NF-κB",

author = "Yuichi Ishikawa and Miyuki Tachibana and Chino Matsui and Rika Obata and Kazuo Umezawa and Shigeru Nishiyama",

note = "Funding Information: This work was supported by High-Tech Research Center Project for Private Universities: matching fund subsidy from MEXT, 2006–2011. ",

year = "2009",

month = mar,

day = "15",

doi = "10.1016/j.bmcl.2009.01.107",

language = "English",

volume = "19",

pages = "1726--1728",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "6",

}

TY - JOUR

T1 - Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

AU - Ishikawa, Yuichi

AU - Tachibana, Miyuki

AU - Matsui, Chino

AU - Obata, Rika

AU - Umezawa, Kazuo

AU - Nishiyama, Shigeru

N1 - Funding Information: This work was supported by High-Tech Research Center Project for Private Universities: matching fund subsidy from MEXT, 2006–2011.

PY - 2009/3/15

Y1 - 2009/3/15

N2 - Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.

AB - Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.

KW - 9-Methylstreptimidone

KW - Inhibitor

KW - NF-κB

UR - https://www.scopus.com/pages/publications/61349093025

UR - https://www.scopus.com/pages/publications/61349093025#tab=citedBy

U2 - 10.1016/j.bmcl.2009.01.107

DO - 10.1016/j.bmcl.2009.01.107

M3 - Article

C2 - 19231181

AN - SCOPUS:61349093025

SN - 0960-894X

VL - 19

SP - 1726

EP - 1728

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

抄録

ASJC Scopus subject areas

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル