Synthesis and structure-activity relationships for cytotoxicity and apoptosis-inducing activity of (+)-halichonine B

Ichiro Hayakawa, Tomomi Nakamura, Osamu Ohno, Kiyotake Suenaga, Hideo Kigoshi

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Halichonine B is a sesquiterpene alkaloid isolated from the marine sponge Halichondria okadai Kadota. Halichonine B has exhibited cytotoxicity against mammalian cancer cells and induced apoptosis in the human leukemia cell line HL60. Here we established a practical route for the synthesis of halichonine B and its analogues, and we evaluated their biological activities. It was revealed that the secondary amino groups in the side chain portion are important for the strong cytotoxicity of halichonine B and that the N11-prenyl group is unimportant. Halichonine B and its analogues were also observed to induce apoptosis in HL60 cells.

本文言語English
ページ(範囲)9969-9976
ページ数8
ジャーナルOrganic and Biomolecular Chemistry
13
39
DOI
出版ステータスPublished - 2015 8月 11

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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