Synthesis of chiloscyphones and the biological activities of their synthetic intermediates against methicillin-resistant Staphylococcus aureus (MRSA)

Junichi Shiina; Rika Obata; Hiroshi Tomoda; Shigeru Nishiyama

doi:10.1002/ejoc.200500928

Synthesis of chiloscyphones and the biological activities of their synthetic intermediates against methicillin-resistant Staphylococcus aureus (MRSA)

Junichi Shiina, Rika Obata, Hiroshi Tomoda, Shigeru Nishiyama

研究成果: Article › 査読

6 被引用数 (Scopus)

抄録

The total syntheses of chiloscyphone (1) and isochiloscyphone (2) have been achieved. Furthermore, the synthetic intermediate 5 shows biological activity against methicillin-resistant Staphyrococcus aureus, and compounds 5, 17, and 18, display imipenem-type activity. The tricyclic lactone framework, which includes an α,β-unsaturated ketone moiety, might play a crucial role in the anti-MRSA activity.

本文言語	English
ページ（範囲）	2362-2370
ページ数	9
ジャーナル	European Journal of Organic Chemistry
号	10
DOI	https://doi.org/10.1002/ejoc.200500928
出版ステータス	Published - 2006 5月 12
外部発表	はい

ASJC Scopus subject areas

物理化学および理論化学
有機化学

文献へのアクセス

10.1002/ejoc.200500928

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引用スタイル

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