@article{185d280afe5a44709b73a9fca878355c,
title = "Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity",
abstract = "Mincle, expressed in activated phagocytes, recognizes the lipid ligand to activate the innate immune system. We have synthesized glycerol derivatives possessing simple alkyl chains or aromatic rings and elucidated their structure-activity relationships using a Mincle-mediated signaling assay. The activity depends on the length of the simple acyl chains of the glycerol derivatives.",
author = "Takanori Matsumaru and Risa Ikeno and Yusuke Shuchi and Toshiki Iwamatsu and Takashi Tadokoro and Sho Yamasaki and Yukari Fujimoto and Atsushi Furukawa and Katsumi Maenaka",
note = "Funding Information: This research was partially supported by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED under Grant Number 18am0101093j and the Middle Molecule Project from AMED under Grant Number 18ae0101047h, Hokkaido University, the Global Facility Center (GFC), the Pharma Science Open Unit (PSOU), funded by MEXT under the {\textquoteleft}{\textquoteleft}Support Program for Implementation of New Equipment Sharing System{\textquoteright}{\textquoteright}, the Hokkaido University Biosurface project, the Takeda Science Foundation, the Akiyama Life Science Foundation and a Grant-in-Aid for Scientific Research from Japan Society of the Promotion Science under Grant number JP17H02207. We also thank Mr D. Yoshidome for three-dimensional structure analysis. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",
year = "2019",
doi = "10.1039/C8CC07322H",
language = "English",
volume = "55",
pages = "711--714",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "5",
}