Synthesis of new peptidic glycoclusters derived from β-alanine. Part 2: Optionally modulated distance between side-chain branched points

Noriyasu Hada, Koji Sato, Yuhua Jin, Tadahiro Takeda

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The synthesis of an asymmetric glycocluster 1 has been achieved using two glycocluster units 12 and 13, prepared by coupling the cluster chain unit 4 with each ω-amino acid (β-alanine and 6-aminocapronic acid) trichloroethyl ester, and peptidic C-terminal block glycocluster 16, prepared by coupling the bifunctional linker 14 with sugar unit 9. This method facilitated the synthesis of the cluster optionally modulated the distance between the side-chain branched points by using various ω-amino acids. We also synthesized glycodendron 2 using the same intermediate.

本文言語English
ページ(範囲)1131-1135
ページ数5
ジャーナルChemical and Pharmaceutical Bulletin
53
9
DOI
出版ステータスPublished - 2005 9月

ASJC Scopus subject areas

  • 化学一般
  • 創薬

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