Synthesis of (+)-vinblastine and its analogues

Tohru Miyazaki; Satoshi Yokoshima; Siro Simizu; Hiroyuki Osada; Hidetoshi Tokuyama; Tohru Fukuyama

doi:10.1021/ol702040y

Synthesis of (+)-vinblastine and its analogues

Tohru Miyazaki
, Satoshi Yokoshima
, Siro Simizu
, Hiroyuki Osada
, Hidetoshi Tokuyama
, Tohru Fukuyama

研究成果: Article › 査読

69 被引用数 (Scopus)

抄録

(Chemical Equation Presented) A synthetic route to vinblastine and its analogues with an ethynyl group, which features a stereoselective coupling of an 11-membered key intermediate with vindoline, is described. Transformations of the alkynyl moiety including a partial reduction as well as a Sonogashira coupling furnished a variety of analogues.

本文言語	English
ページ（範囲）	4737-4740
ページ数	4
ジャーナル	Organic Letters
巻	9
号	23
DOI	https://doi.org/10.1021/ol702040y
出版ステータス	Published - 2007 11月 8
外部発表	はい

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1021/ol702040y

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引用スタイル

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AU - Simizu, Siro

AU - Osada, Hiroyuki

AU - Tokuyama, Hidetoshi

AU - Fukuyama, Tohru

PY - 2007/11/8

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AB - (Chemical Equation Presented) A synthetic route to vinblastine and its analogues with an ethynyl group, which features a stereoselective coupling of an 11-membered key intermediate with vindoline, is described. Transformations of the alkynyl moiety including a partial reduction as well as a Sonogashira coupling furnished a variety of analogues.

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Synthesis of (+)-vinblastine and its analogues

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