Synthetic studies of erythromycin derivatives syntheses and antimicrobial activities of 3”-Epi-erythromycin A and (9S) 11-dehydroxy-9-deoxo-9-hydroxy-11-oxoerythromycin A

Masaya Nakata; Tetsuro Tamai; Yukiko Miura; Mitsuhiro Kinoshita; Kuniaki Tatsuta

doi:10.7164/antibiotics.46.813

Synthetic studies of erythromycin derivatives syntheses and antimicrobial activities of 3”-Epi-erythromycin A and (9S) 11-dehydroxy-9-deoxo-9-hydroxy-11-oxoerythromycin A

Masaya Nakata, Tetsuro Tamai, Yukiko Miura, Mitsuhiro Kinoshita, Kuniaki Tatsuta

応用化学科

研究成果: Article › 査読

7 被引用数 (Scopus)

抄録

Two new derivatives, 3”-epi-erythromycin A (2) and (9S)-11-dehydroxy-9-deoxo-9-hydroxy-11-oxoerythromycin A (3), have been synthesized by using glycosylation with glycal (Ferrier rearrangement), bromomethoxylation and bis(tributyltin) oxide-bromine oxidation as the key steps. Their antimicrobial activities were compared with those of erythromycin A (1).

本文言語	English
ページ（範囲）	813-826
ページ数	14
ジャーナル	Journal of Antibiotics
巻	46
号	5
DOI	https://doi.org/10.7164/antibiotics.46.813
出版ステータス	Published - 1993 5月

ASJC Scopus subject areas

薬理学
創薬

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10.7164/antibiotics.46.813

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引用スタイル

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