Synthetic studies of the spirocyclic cyclohexene part of versipelostatin, a novel GRP78/Bip molecular chaperone downregulator

Keyphrases

• Glucose-regulated Protein 78 (GRP78) 100%
• Synthetic Study 100%
• Cyclohexanone 100%
• Cyclohexene 100%
• Molecular Chaperone 100%
• Spirocyclic 100%
• Ring-closing Metathesis 100%
• Substructure 50%
• Asymmetric Synthesis 50%
• Carboxylic Acids 50%
• High Yielding 50%
• Stereoselectivity 50%
• D-glucose 50%
• Enantiomerically Pure 50%
• Dimethyl Malonate 50%
• Esterified 50%
• Tetra-substituted 50%
• 4-dione 50%
• Chiral Template 50%
• Diester 50%
• Tetronic Acid 50%
• Stereoselective Allylation 50%
• Decen 50%
• Spirocyclic Tetronic Acid 50%
• Acylated 50%

Chemistry

• Chaperone Protein 100%