Synthetic studies on glycosphingolipids from protostomia phyla: Synthesis of glycosphingolipid from the marine sponge Spheciospongia vesparia and its analogue

Stereocontrolled syntheses of a neutral glycosphingolipid found from a marine sponge Spheciospongia vesparia and its analogue have been accomplished. Disaccharide glycosphingolipids, β-D-Arap-(1→6)-β-D-Glcp-(1↔1)-Cer (1) and α-D-Arap-(1→6)-β-D-Glcp-(1↔1)-Cer (2), were synthesized from suitable monosaccharide donors and an acceptor by stepwise synthesis.