抄録
MicroRNAs (miRNAs) are short noncoding RNAs and can regulate gene expression at the transcriptional and/or translational levels. There is mounting evidence that miRNAs play an important role in the control of the dynamics of localized gene expression. Expression profiling of miRNA in various cancers revealed that miRNA profiles could discriminate malignancies from their counter parts. In this study, to investigate the localized effect of miRNA in cancer, we analyzed gene and miRNA expressions in hepatocellular carcinoma (HCC) and surrounding nontumor tissues. Based on gene expression levels around miRNAs, we investigated how many miRNAs correlated positively/negatively in expression with genes in the vicinity. Next, the Pearson correlation coefficients were compared between the HCC and nontumor tissues. The results imply that the relationship between the intronic miRNAs and their host genes was altered in HCC, and that feedback loops including the host gene, intronic miRNA, target genes might be formed in HCC.
| 本文言語 | English |
|---|---|
| ホスト出版物のタイトル | 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 |
| ページ | 600-603 |
| ページ数 | 4 |
| DOI | |
| 出版ステータス | Published - 2013 |
| イベント | 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan 継続期間: 2013 7月 3 → 2013 7月 7 |
出版物シリーズ
| 名前 | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
|---|---|
| ISSN（印刷版） | 1557-170X |
Other
| Other | 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 |
|---|---|
| 国/地域 | Japan |
| City | Osaka |
| Period | 13/7/3 → 13/7/7 |
ASJC Scopus subject areas
- 信号処理
- 生体医工学
- コンピュータ ビジョンおよびパターン認識
- 健康情報学
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
