@article{44794b1fb9e945c68f8928ee6075c352,
title = "TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity",
abstract = "Mechanisms by which endothelial cells (ECs) maintain themselves in inflammatory microenvironments remain unclear. Naito et al. show that TAK1 prevents EC apoptosis induced by TNF-α-expressing myeloid cells. TAK1 protects ECs and ensures the maintenance of vascular integrity and homeostasis under inflammatory conditions.",
keywords = "TAK1, TNF-α, apoptosis, inflammation, intestinal microbiota, tumor angiogenesis, vascular homeostasis",
author = "Hisamichi Naito and Tomohiro Iba and Taku Wakabayashi and Ikue Tai-Nagara and Suehiro, {Jun ichi} and Weizhen Jia and Daisuke Eino and Susumu Sakimoto and Fumitaka Muramatsu and Hiroyasu Kidoya and Hiroyuki Sakurai and Takashi Satoh and Shizuo Akira and Yoshiaki Kubota and Nobuyuki Takakura",
note = "Funding Information: We thank Dr. Hiroshi Seno (Kyoto University Graduate School of Medicine, Japan) for helpful discussions on this study. We also thank Ms. M. Ishida, Ms. N. Fujimoto, and Ms. Y. Mori for technical assistance; Ms. H. Omori for technical support in the electron microscope study; and Ms. Y. Kabumoto and Ms. Y. Uchikawa for cell sorting. This work was supported by the Japan Agency for Medical Research and Development (AMED) under Grant number 18cm0106508h0003, 18gm5010002s1102; AMED-PRIME under Grant number 18gm6210009h0001; the Japan Society for the Promotion of Science (JSPS) (Grants-in-Aid for Scientific Research A 16H02470); a research grant of Astellas Foundation for Research on Metabolic Disorders; the Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University; and a research grant of Takeda Science Foundation. Funding Information: We thank Dr. Hiroshi Seno (Kyoto University Graduate School of Medicine, Japan) for helpful discussions on this study. We also thank Ms. M. Ishida, Ms. N. Fujimoto, and Ms. Y. Mori for technical assistance; Ms. H. Omori for technical support in the electron microscope study; and Ms. Y. Kabumoto and Ms. Y. Uchikawa for cell sorting. This work was supported by the Japan Agency for Medical Research and Development (AMED) under Grant number 18cm0106508h0003 , 18gm5010002s1102 ; AMED-PRIME under Grant number 18gm6210009h0001 ; the Japan Society for the Promotion of Science (JSPS) (Grants-in-Aid for Scientific Research A 16H02470 ); a research grant of Astellas Foundation for Research on Metabolic Disorders ; the Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives , Osaka University ; and a research grant of Takeda Science Foundation . Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = jan,
day = "28",
doi = "10.1016/j.devcel.2018.12.002",
language = "English",
volume = "48",
pages = "151--166.e7",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "2",
}