@article{ad43c529b72f4de4a969866d0d1f4557,
title = "Target-Selective Fluorescence Imaging and Photocytotoxicity against H2O2 High-Expressing Cancer Cells Using a Photoactivatable Theranostic Agent",
abstract = "A purpose-designed and synthesized H2O2-reactive and photoactivatable theranostic agent 1 consisting of 1) an arylboronic acid moiety, 2) pro-fluorophore moiety, and 3) photoactivatable moiety (photosensitizer), selectively and effectively reacted with H2O2 while simultaneously releasing resorufin for fluorescence detection under neutral aqueous conditions. In addition, 1 was cell-permeable, and exhibited effective photocytotoxicity against fluorescently visualized cells only upon photoirradiation. The results also showed that 1 produced a selective fluorescence response to H2O2, even in living cultured cells.",
keywords = "cytotoxicity, fluorescent probes, peroxides, sensitizers, theranostics",
author = "Ryoma Takagi and Ayano Takeda and Daisuke Takahashi and Kazunobu Toshima",
note = "Funding Information: Strategic Research Foundation at Private Universities, 2012– 2016 (No. S1201020), JSPS KAKENHI Grant Numbers JP16H01161 in Middle Molecular Strategy and Scientific Research (B) (No. 26282212), and Keio Gijuku Academic Development Funds. Funding Information: We wish to thank Prof. Dr. Siro Simizu of the Faculty of Science and Technology, Keio University, for helpful discussions regarding the fluorescence microscopy experiments. This research was supported in part by the MEXT-supported Program for the Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2017",
month = oct,
day = "18",
doi = "10.1002/asia.201701004",
language = "English",
volume = "12",
pages = "2656--2659",
journal = "Chemistry - An Asian Journal",
issn = "1861-4728",
publisher = "John Wiley and Sons Ltd",
number = "20",
}
