@article{491963662ead45e3b9b524f3dc5fdd8f,
title = "Targeting mitochondrial ATP-sensitive potassium channels - A novel approach to neuroprotection",
abstract = "Mitochondrial responses to ischemic stress play an important role in necrosis and apoptosis of brain cells. Recent studies using several different experimental preparations have shown that activation of ATP-sensitive potassium channels in mitochondria (mitoK ATP channels) is able to protect neurons and astroglia against injury and death. Thus, targeting of mitoK ATP channels appears to be a novel approach to neuroprotection. However, little is known about the mechanisms involved. The purpose of this review is to detail the current state of knowledge about this important, emerging area of investigation, and to provide suggestions for future studies.",
keywords = "Apoptosis, Diazoxide, Inwardly rectifying potassium channel, Ischemia, Mitochondrion, Necrosis, Sulfonylurea receptors",
author = "Busija, {David W.} and Zsombor Lacza and Nishadi Rajapakse and Katsuyoshi Shimizu and B{\'e}la Kis and Ferenc Bari and Ferenc Domoki and Takashi Horiguchi",
note = "Funding Information: This work was supported by NIH grants HL-30260, HL-46558, DK 62372, HL-50587, HL-65380, HL-66074, and AHA Bugher Foundation Award 0270114N. Z. Lacza was partially supported by the Hungarian National E{\"o}tv{\"o}s Fellowship. We thank Nancy Busija, M.A., for the assistance in editing the manuscript.",
year = "2004",
month = nov,
doi = "10.1016/j.brainresrev.2004.06.011",
language = "English",
volume = "46",
pages = "282--294",
journal = "Brain Research Reviews",
issn = "0165-0173",
publisher = "Elsevier",
number = "3",
}