TY - JOUR
T1 - Technetium-99m complexes with steroid-2-aminooxyethyliminodiacetic acid conjugates
AU - Yoda, Reiko
AU - Karube, Yoshiharu
AU - Takata, Jiro
AU - Nagata, Yoshiko
AU - Matsushima, Yoshikazu
PY - 1999/3
Y1 - 1999/3
N2 - Conjugates of 2-aminooxyethyliminodiacetic acid with estrone, testosterone, epiandrosterone, 17-α-hydroxy-progesterone and progesterone were synthesized and their complexes with Tc-99m were successfully prepared in good yields, which indicated the agent to be promising for metal-labeling of biomolecules and related substances containing one or more carbonyl groups. The biodistribution and scintigraphic studies in mice bearing Ehrlich tumor and mammary tumor showed that the radioactivity accumulated considerably in the tumor tissues, but the tumor images were somewhat obscured.
AB - Conjugates of 2-aminooxyethyliminodiacetic acid with estrone, testosterone, epiandrosterone, 17-α-hydroxy-progesterone and progesterone were synthesized and their complexes with Tc-99m were successfully prepared in good yields, which indicated the agent to be promising for metal-labeling of biomolecules and related substances containing one or more carbonyl groups. The biodistribution and scintigraphic studies in mice bearing Ehrlich tumor and mammary tumor showed that the radioactivity accumulated considerably in the tumor tissues, but the tumor images were somewhat obscured.
KW - 2-aminooxyethyliminodiacetic acid
KW - Bifunctional chelating agent Ehrlich tumor
KW - Estrone
KW - Mammary tumor
KW - Technetium-99m
UR - http://www.scopus.com/inward/record.url?scp=0032893826&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032893826&partnerID=8YFLogxK
U2 - 10.1248/cpb.47.413
DO - 10.1248/cpb.47.413
M3 - Article
C2 - 10212390
AN - SCOPUS:0032893826
SN - 0009-2363
VL - 47
SP - 413
EP - 416
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 3
ER -