@article{de287d736d4249b89b1156458ab0ab24,
title = "The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression",
abstract = "The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19 ARF or human p14 ARF binds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression.",
keywords = "ARF, BCL6, Tumor suppressor, p14, p19",
author = "Hiroaki Suzuki and Megumi Kurita and Kiyohisa Mizumoto and Masatsugu Moriyama and Sadakazu Aiso and Ikuo Nishimoto and Masaaki Matsuoka",
note = "Funding Information: We are indebted to Dr. Masaki Kitajima for essential support to this study. We thank Dr. V.J. Bardwell for the plasmid encoding BCL6, Drs. T. Tokuhisa and M. Hatano for the 2× BS-Luc plasmid, Drs. C.J. Sherr and M.F. Roussel for MEFs. We are indebted to Tomo Yoshida, Takako Hiraki, and Dovie Wylie for expert technical assistance. This work was supported in part by Japan Society for the Promotion of Science.",
year = "2004",
month = dec,
day = "31",
doi = "10.1016/j.bbrc.2004.11.016",
language = "English",
volume = "326",
pages = "242--248",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "1",
}