The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs

Yuko Atsumi; Aki Inase; Tomoyuki Osawa; Eiji Sugihara; Ryo Sakasai; Hiroaki Fujimori; Hirobumi Teraoka; Hideyuki Saya; Masamoto Kanno; Fumio Tashiro; Hitoshi Nakagama; Mitsuko Masutani; Ken Ichi Yoshioka

doi:10.1074/jbc.M112.402560

The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs

Yuko Atsumi, Aki Inase, Tomoyuki Osawa, Eiji Sugihara, Ryo Sakasai, Hiroaki Fujimori, Hirobumi Teraoka, Hideyuki Saya, Masamoto Kanno, Fumio Tashiro, Hitoshi Nakagama, Mitsuko Masutani, Ken Ichi Yoshioka

研究成果: Article › 査読

24 被引用数 (Scopus)

抄録

Background: It is unclear how DNA-damaging agents target cancer cells over normal somatic cells. Results: Arf/p53-dependent down-regulation of H2AX enables normal cells to survive after DNA damage. Conclusion: Transformed cells, which harbor mutations in either Arf or p53, are more sensitive to DNA-damaging agents. Significance: Cellular transformation renders cells more susceptible to some DNA-damaging agents.

本文言語	English
ページ（範囲）	13269-13277
ページ数	9
ジャーナル	Journal of Biological Chemistry
巻	288
号	19
DOI	https://doi.org/10.1074/jbc.M112.402560
出版ステータス	Published - 2013 5月 10
外部発表	はい

ASJC Scopus subject areas

生化学
分子生物学
細胞生物学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1074/jbc.M112.402560

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引用スタイル

Atsumi, Y., Inase, A., Osawa, T., Sugihara, E., Sakasai, R., Fujimori, H., Teraoka, H., Saya, H., Kanno, M., Tashiro, F., Nakagama, H., Masutani, M., & Yoshioka, K. I. (2013). The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs. Journal of Biological Chemistry, 288(19), 13269-13277. https://doi.org/10.1074/jbc.M112.402560

Atsumi, Y, Inase, A, Osawa, T, Sugihara, E, Sakasai, R, Fujimori, H, Teraoka, H, Saya, H, Kanno, M, Tashiro, F, Nakagama, H, Masutani, M & Yoshioka, KI 2013, 'The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs', Journal of Biological Chemistry, vol. 288, no. 19, pp. 13269-13277. https://doi.org/10.1074/jbc.M112.402560

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AU - Sugihara, Eiji

AU - Sakasai, Ryo

AU - Fujimori, Hiroaki

AU - Teraoka, Hirobumi

AU - Saya, Hideyuki

AU - Kanno, Masamoto

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