@article{3df87eefcde9459696abc97c122e5d16,
title = "The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development",
abstract = "Cochlear development is a complex process with precise spatiotemporal patterns. A detailed understanding of this process is important for studies of congenital hearing loss and regenerative medicine. However, much of our understanding of cochlear development is based on rodent models. Animal models that bridge the gap between humans and rodents are needed. In this study, we investigated the development of hearing organs in a small New World monkey species, the common marmoset (Callithrix jacchus). We describe the general stages of cochlear development in comparison with those of humans and mice. Moreover, we examined more than 25 proteins involved in cochlear development and found that expression patterns were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Human fetal samples for studies of primate-specific cochlear development are extremely rare, especially for late developmental stages. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.",
keywords = "cochlea, common marmoset, inner ear, primate",
author = "Makoto Hosoya and Masato Fujioka and Murayama, {Ayako Y.} and Hideyuki Okano and Kaoru Ogawa",
note = "Funding Information: We thank Ayano Mitsui, Saki Ninomiya, and Junko Okahara for technical support and Takeshi Inoue for providing materials. MH was supported by a grant from the Japanese government MEXT KAKENHI (Grant‐in‐Aid for Early‐Career Scientists, 18K16856), the Keio Medical Association and Keio University Medical Science Fund, the Society for Promotion of International Oto‐Rhino‐Laryngology (SPIO), and Keio Gijuku Academic Development Funds. This research was also partially supported by grants to MF from the Japanese government MEXT KAKENHI (Grant‐in‐Aid for Scientific Research (A) 18H04065, 19H05473), Keio Gijuku Academic Development Funds, foundation from Mitsubishi Tanabe, and the Takeda Science Foundation. This research was also partially supported by a Grant for Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS). Funding Information: We thank Ayano Mitsui, Saki Ninomiya, and Junko Okahara for technical support and Takeshi Inoue for providing materials. MH was supported by a grant from the Japanese government MEXT KAKENHI (Grant-in-Aid for Early-Career Scientists, 18K16856), the Keio Medical Association and Keio University Medical Science Fund, the Society for Promotion of International Oto-Rhino-Laryngology (SPIO), and Keio Gijuku Academic Development Funds. This research was also partially supported by grants to MF from the Japanese government MEXT KAKENHI (Grant-in-Aid for Scientific Research (A) 18H04065, 19H05473), Keio Gijuku Academic Development Funds, foundation from Mitsubishi Tanabe, and the Takeda Science Foundation. This research was also partially supported by a Grant for Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS). Publisher Copyright: {\textcopyright} 2020 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies",
year = "2021",
month = jan,
doi = "10.1111/febs.15341",
language = "English",
volume = "288",
pages = "325--353",
journal = "FEBS Journal",
issn = "1742-464X",
publisher = "Wiley-Blackwell",
number = "1",
}
